There is
an interesting intellectual war going on right now, between scientist/author
Siddhartha Mukherjee and molecular geneticists.
It was precipitated by Mukherjee’s recent
article in The New Yorker on the
wonderful world of epigenetics.
Geneticist
Jerry Coyne
objected stridently to the
New Yorker essay. Now, Coyne is one of those people who thinks that a real
scientist should not be able to tell a human from an ape, and has
chastised me
in the past for being able to. Such
people are either
deaf, dumb, and blind, or else they don’t think that the
choice to privilege genetic relations (which make it hard to tell humans from
apes) over ecological relations (where it is really, really easy to tell humans
from apes) requires a justification. In fact, in the 1960s,
G. G. Simpson demanded such a justification, and never got one. Historians like Marianne
Sommer, Joel
Hagen, and Michael
Dietrich have been writing about it.
Mukherjee
is
responding to his critics.
Anyway, since I already knew that Coyne is apparently not very good at
confronting his intellectual prejudices, I thought it might be a good time to reconsider
just what is at stake intellectually in this epigenetics business. I talked about this a little in my
Annual Review of Anthropology article a
few years ago. But actually it’s a nice
example of how understanding the science can be helped by asking the lawyerly
question “Cui bono?” (who benefits?). And
further, it helps to show that this isn’t a controversy of biology, but of biopolitics.
Point
#1: Human genetics is invariably biopolitical. To see this point, you must
grapple with the history of human genetics.
Not the history as told by scientists, the time-line approach that
begins, “Once upon a time there was Archibald Garrod...” – but the history as
told by historians. That’s the history
that looks at what scientists said to the public, and at the associated social relations. The twentieth century, after all, began with
eugenics and ended with “
genohype” – which no sensible geneticist wants to
defend today.
And we
nearly span the century when we compare the concluding statement of the first
textbook of
Mendelism (1905) with the director of the Human Genome Project’s
comment to
Time Magazine in 1989. First, the eponymous Reginald C. Punnett,
remembered in science today for his square:
“As our knowledge of heredity clears
and the mists of superstition are dispelled, there grows upon us with an ever
increasing and relentless force the conviction that the creature is not made
but born.”
Ummm,
WTF? Granted, genetics was important
enough to him to write a book about, but the message that “the creature is not
made but born” is certainly not its central message. Its central message is about how the creature gets born – not that
the facts of birth are the only important things about it.
Compare
James Watson: “We used to think our fate was in the stars. Now we know, in large measure, our fate is in
our genes.”
Now, I
know, throwing out Watson quotes is hardly even fun any more, and nobody in
science really believes him. But let me
just remind you that he knows more about DNA than you do, and he has a fucking
Nobel Prize. What have you got?
What these two thoughts have in common, 84 years and a whole
lot of data and theory apart, is their biopolitics. They are saying something very important, and
it’s not about fruitflies, nor is it about the ABO blood group. It’s about your lot in life. It’s about who you are, and what you can aspire
to become. And it’s a fairly pessimistic note, if your origins are humble: You
can never transcend you ancestors. Read it:
The creature is not
made, but born.
Our fate is in our
genes.
Your personal
development is strictly limited by your ancestry.
Now, that is a message that resonates far beyond genetics. It is familiar to readers of 1994's
The Bell Curve,
for instance, whose authors were a psychologist and a political theorist. It is there in the 19
th century political
writings of
Arthur de Gobineau. It is
also familiar to readers of pre-modern geneticists, such as August Weismann and
Francis
Galton.
What is
interesting in the present context is the broad opposition to that pessimistic
statement, and the alternative scientific venues for studying how the creature
is indeed made, our fates are not in our genes, and we can become different
from our ancestors.
One such
venue, which was popular in the late 19
th and early 20
th
centuries, was the inheritance of acquired characteristics, often known as
Lamarckism. This of course petered out with the suicide of Paul Kammerer in the 1920s, but has
never been entirely buried. Bipedalism, after all, was a behavioral choice made by our ancestors, for which we no longer have a choice.
Another venue for studying how we are made is
culture, which eventually superseded eugenics as the favored mode of
improving society in the 20
th century.
So over
the course of the 20th century, we actually learned that, despite
the biopolitical rhetoric of geneticists, there were in fact several significant ways in
which you could become different from your ancestors and not necessarily be
limited by them.
The scientistic
rhetoric turned once again with the Human Genome Project in the 1980s. To get
that program off the ground, molecular geneticists groomed the public with
sound-bites like James Watson’s. Then
(like the eugenicists of the 1920s) they embarked on a wildly successful public education program,
to convince taxpayers that three billion dollars to sequence the human genome would
be the best three billion dollars we ever spent.
And a
wave of purple scientific prose flowed in its wake. Remember “
Mapping the Code”? That’s still my favorite mixed metaphor. And “
Mapping our Genes”? And “
The Human Blueprint”? And “
The Book of Man”? How
about “
The Code of Codes”? (I still don't know what that actually means, except that it is vaguely evocative of Jesus as "
King of Kings," and of The Godfather, as "
capo di tutti capi".) Remember how
the Human Genome Project was the most important scientific revolution since
Galileo and we were going to know what it meant to be human and cure all genetic
diseases and stuff?
Ah well,
the important thing is, they got the money.
So what if the public transiently believed that your DNA code was the
most important thing about you? Hey, it's just a hypothesis. And it might be true, right?
Let’s
now answer the question “Cui bono?” Who
benefits by having the educated public misbelieve that your DNA code is the
most important thing about you? Two principal
groups – just as in the 1920s. First
off, the one percent – those now favored by nature, not merely by avarice or luck or unscrupulousness - and who are inclined
to try and give their own kids a financial leg up in this dog-eat-dog world, rather than redistribute the wealth in the form of public goods and services that
might permit others to compete more fairly in that world.
And
second, the molecular geneticists – the ones now studying the most important
thing about you. Your DNA code. In fact, anything’s DNA code. It’s also The Frog Blueprint and The Book of
Frog. That is Point #2: It is in the interests of the molecular geneticists to have you believe that everything important about you lies in the field of molecular genetics.
That is a significant convergence of interests with the one percent. Back to
history.
By the
late 1930s, the developmental geneticist C. H.
Waddington was distinguishing between
the kind of information in a human cell that distinguishes one person from
another (genetic) and the kind of information that distinguishes one cell type
from another, with identical DNA sequences (epigenetic). Waddington’s
reputation had been all but eclipsed in genetics, when Stephen Jay Gould
revived him in evolutionary biology, specifically in the call for an
evolutionary science of organismal form, rather than the reductive evolutionary
science that was normative in the 1980s.
Epigenetics
is a label for the non-reductive study of heredity. You are no longer just your ancestors’ DNA
sequences, but also their methylation and transcriptional regulation
patterns. But more significantly, your genetics
is far more conservative than your epigenetics.
Your “epigenome” is responsive to the environment; that is to say, it adapts. And it does so far more rapidly and directly
than your genome does.
That extends
our list of alternative scientific venues for studying your non-DNA-sequence-based self just a bit. In addition to the study of possible Lamarckian
inheritance, culture, and human adaptability, there is now epigenetics. In other words, the significance of
epigenetics lies in its biopolitical role as a reaction against the genetic
determinism, or
hereditarianism, that accompanied the Human Genome Project.
There
is, in fact, a lot more at stake than just transcription factors. The smart geneticists already know that.
Waddington,
it turns out, was a very smart one. He
was a broad intellectual, and actually wrote a book about
art at the end of his
life. I don’t think he was that big of a
Marxist, as Mukherjee suggests, although he was certainly left of center
politically, and was instrumental in getting the famous University of Edinburgh
science studies program going (known as the “strong programme”).
Waddington’s
biology was also always very well-informed anthropologically. When he and his wife visited New York they
always stayed with Margaret Mead. Why?
Because Waddington’s BFF from college days at Cambridge was Mead’s third
husband, Gregory
Bateson. (Waddington’s
daughter is a distinguished Cambridge social anthropologist.) The major influence on Bateson and on
Waddington was not the philosopher Marx, but the philosopher Alfred North
Whitehead, also very much the anti-reductionist, but a bit more spiritual.
At least
I think so. He may have been less
impenetrable in person. He’s fucking tough in print.
Gregory Bateson’s 1936 ethnography
Naven acknowledges some influence of
Waddington and Whitehead in a
footnote.